I imagine the response will be on the line of: “our security team assessed the use of such airspace in compliance with our strict security requirements, in coordination with government agencies and so on… are you refusing to carry out your planned duty Captain?”
You know the ME can have a somehow fragile political stability at times, and a local carrier will overfly hotspots such as Yemen, Somalia, South Sudan, Syria, Iran, etc.
They have specific restrictions and procedures in place for each airspace, including prohibited airspaces. I doubt you refusing to fly over an “approved airspace” will go down very well with management.