Not a pilot just an avionics specialist, but if it was a simple case of simultaneous myocardial infarctions taking out both P1 and P2 I could manage a 757 or 767 without any trouble.
However if it was a case of the pilots refusing to continue after a Cessna had been through the windscreen, I'd need a competent CSO to assist by ripping the P5 Panel out with her bare hands and chucking it out of the hole.