Hobo,
Could you tell us which OS are you running and what type of Popups are you getting? Are they Internet Explorer Popups or Messenger Popups?
Also download and run
Lavasoft's Ad-Aware so we can see if your computer has an Malware on it. (Another excellent program is Spybot.)
Take Care,
Richard
P.S. Popup blockers work, but they can just mask your problem if you have Malware installed on your computer.