ASK-13,
My first reaction was "no" but now I'm now so sure of that as a blanket answer. It may be different for domestic vs international Part 135 ? I did look at Part 135 PIC requirements and saw no mention of a maximum age.
I tried to research the question but quickly saw it's a regulatory rabbit hole which I'm too lazy to jump into. Here's something:
https://www.airlinepilotforums.com/p...-135-icao.html