I had a similar problem with a seldom used secondary work laptop mid last year. It wanted to apply the then latest Microsoft patches when I booted it up and after that the GUI went nuts with using either the mouse or the trackpad to scroll down. I put the laptop away and pulled it out few weeks later and there was another Microsoft patch for it. I installed it and the problem went away. I then researched the patch and found an obscure reference to this issue.
I believe the root cause of the problem is some registry setting that makes Windows go nuts with the pointing device, exactly what that registry setting is I don't know, best to just get the latest patches for Windows.