Have you tried with a plug in mouse ? Seems a bit radical to dump the computer. You could dig up the garden and demolish the house while your at it.
Think I would try uninstalling keyboard and mouse in device manager, all instances, unplug keyboard and mouse, reboot, switch off, reconnect keyboard and mouse start up.
If that doesn't work, and you can't be bothered reseting the bios, torch the f*cker.