Have always, when operating heavy jets, had a look at the takeoff figures, and wondered...is this reasonable?
Sometimes it is not, on more than one occasion.
Common sense should prevail.
Don't be like the SQ crew who taxied to R27 in MEL ( a long time ago), when the weight required R34....take the time for a reasonable look at the probabilities that the numbers just might be wrong.
Of course in helps if you have a really switched on Flight Engineer, but with two crew types, even more important.