Cannot say much, but the advice Dutchless_Driver give are sound.
The northern route is Iqualuit (Frobisher Bay/CYFB) - Kangerlussuaq (Sondrestrom/BGSF) - Kulusuk (BGKK) - Reykjavik (BIRK).... Instead of Sondrestrom, both Ilulissat (BGJN) and Nuuk (BGGH) are also options, though the weather here is a little more unstable.
Weather is often very stable in Sondrestrom, but it gets freezing in wintertime, with the lowest I've experienced was minus 46 centigrade, and then you really have trouble starting most aircraft... we usually cease flying in minus 20 centigrade, but we also have our aircraft hangared.
If you go this way, the MOCA over the ice is FL120 or higher depending on weather, whereas going via Narsarsuaq you can fly around the south tip of Greenland.
Keep in mind that Narsarsuaq, Sondrestrom, Ilulissat, Kulusuk and Nuuk normally have AVGAS (they do run out, but seldom), but the rest of the airports normally not. So check the AIP and NOTAMS before flight.
http://aim.naviair.dk
And also, the Greenlandic west coast is "littered" with airports, familiarize yourself with their locations before flying, makes it a lot easier in case you have to divert due to weather. We'd preferably have you alive on one of those (and without AVGAS), than sitting somewhere on or, in worst case, in the mountains.
If you intend to fly low-ish, there are radio dead spots over the icecap, but ATS will inform you if that is the case, and when you can get in contact with them again. If needed to communicate, you can always relay via highlevel aircraft crossing Greenland on the highlevel frequencies or the emergency frequency. People flying high are really glad to help with that (remember they're bored up there, and any change to the routine is welcome).