Aerodynamically, it will work, there have been more flying wing designs, that operated well enough (for their mission), and modern technology will certainly help in new areas. The problem with non-fuselage aircraft is the survivable crash landing and the 90 seconds certification rule for evacuation. In that case, the wing leading edge may become distorted and the doors may not open. So other means of evacuation exits must be conceived. Jettisonable trailing edges?