MacOS 10.15.5, Safari 13.1.1, with AdGuard 1.7.4.
Topic pages load ok, individual threads return a blank white page. Pausing ad blocker renders full page but with Safari Developer Console revealing a plethora of security errors linked to Google Syndication:
Blocked a frame with origin "https://tpc.googlesyndication.com" from accessing a frame with origin "https://www.pprune.org". Protocols, domains, and ports must match.