I think the question should be - if the primary objective was to destroy the Luftwaffe - could we have done it more efficiently and effectively.
For example, in the early part of the Battle of Britain, the primary German targets were British airfields, radar, and other air defense facilities. It was working - the RAF was on the verge of collapse until Hitler decided to bomb London instead. Might the Allies have been more effective at destroying the Luftwaffe with a similar campaign had they gone after airfields and the like instead of factories? Granted the necessary level of accuracy likely couldn't be achieved with night bombing.