As for fatigue... try doing 10-12 hour shifts, being on call for 21 days straight for 24 hours a day whilst being responsible for human lives in extremely challenging and dynamic situations and you might find that at the end of the day your profession isn’t so demanding after all.
And when you stuff up, you will probably only kill one person at a time, but you’ll have a signed waiver saying you’re absolved of all blame and your industry mates will circle the wagons and protect you at all costs.
We on the other hand don’t have that luxury so if we stuff up, hundreds die and we’ll be held accountable. (thrown under the bus)
Therefore, the greatest risk to the highest number of people would be in aviation but that doesn’t seem to even be a consideration to you.