On A320, it’s impossible to realign IRS in flight. Only position update if no GPS primary. The newest Airbuses only use GPS for position update in flight. You can’t even do a manual position update unless both GPS are desactivated or failed. The alignment is also automatically done while resetting the ADIRS knob with the GPS coordinates. No pilot input required. And you don’t need to deselect any rad nav. As long as it’s GPS primary it will never use VOR/DME for position update.