Most of the airlines and regionals use a points system to decide if they will interview. I'm not sure of the details of the system but it is something like this:
Degree = X points
Hours = X points
Multi hours = X points
Scheduled airline experience = X points
Etc... you get the idea.
When you hit the magic number your resume pops up to the top of the list and they call you for an interview. At that point it's how well you can lie in an interview room.
Charter companies and corporate companies use their own methods and each one is a little different.
Perhaps a little asking at the various companies might give you a better idea of what matrix they are using and if you will fit the mix.