The worst sim profile I ever heard about came from a German now defunct airline:
Engine start: Hot start condition, once QRH complete successful second start attempt, taxi to runway. On takeoff passing 100 kts, master caution: ELEC - continue takeoff roll, after rotation: engine separation. Once memory items completed: stab trim runaway. Cleared to a VOR to hold and once on the way to the VOR: FMC FAIL. Raw data hold due to radar failure followed by radar vectors for a manually flown single engine visual approach to land.
Reposition for takeoff: engine failure at 100 kts - RTO. Reposition for takeoff, wheel well fire after gear up, vectors to return with gear collapse and evacuation.
Reposition for takeoff: V1 cut with engine flameout and IDG failure, radar vectors for manually flown single engine raw data NDB approach to land.
Quite what the learning outcome of such a profile would be is beyond me...