Question about aerodynamic load and muscle endurance seem a bit academic, if the rudder trim had been set in the correct position it wouldn’t matter.
Even if the aircraft should have flown, I thinks it’s concievable that a startled pilot mere seconds into a flight would experience sensory overload trying to diagnose and rectify that situation, while being low to the ground and also likely confused.
Everyone makes mistakes, everyone’s human.
My takeaway from all of this is to try and be as vigilant with checklists as I can be, to start over from item one if I’m interrupted and to be methodical with their execution.