I'm pleased to say I'm an insider of neither of the organisations you state, but if Now want to keep their route plans secret then they should make sure that info of this nature doesn't go into a semi-public domain otherwise it's bound to end up here (as it just has).
The problem with the BRU schedule? As I see it:
06:00 off LTN to BRU is very early but should be passable
08:20 off LTN to BRU is a bit late - gets you into BRU at 10:30 local
13:45 off LTN to BRU - not a good time for business or leisure
16:15 off LTN to BRU - probably too early for any BRU incoming pax to return from LON for the flight
19:50 off LTN to BRU - too late
08:45 off BRU to LTN probably be OK
11:00 off BRU to LTN - not a good time
16:30 off BRU to LTN will probably be OK
18:55 off BRU to LTN - good time
22:30 off BRU to LTN - might as well be an empty positioning sector
So, out of ten sectors a day, only three or four are at decent timings for business travellers. Brussels doesn't have anything like the leisure travel market that you find on Amsterdam or Paris; if you were doing this schedule on AMS then I think you'd get away with it, but running it on BRU where you don't have much of a leisure market will make it difficult to fill those off-peak sectors.