I've mentioned this in several threads before - I'm left handed with very limited flying experience in Cessna 152/172 and K-13 gliders. I've flown the 152 both left and right seat and had no problem with left hand yoke/right hand throttle or vice versa. Flying the K-13 was different and my natural hand on the stick was certainly the left and it would take considerable practice to get used to flying righted with the same precision. Aero tows were a bit tricky!
Oddly enough, I write left handed, use a spoon left handed, fork in left hand knife in right, yet I am utterly right handed when it comes to using a computer mouse (doing complicated and intricate graphics work) or on the odd occasion I've played cricket or golf.