Quite well - and you shouldn't be surprised. These guys aren't passengers - they have completed a couple of years of high quality training.
I fly regularly with low hour MPLs and they are very good, their experience only shows up at the very limits of the operation (very high winds, highly contaminated runways) - and our airline had a Captain incapacitation with a new MPL on board a couple of months ago. The FO diverted to an unfamiliar airfield in Italy in strong winds and landed without problems. As he was trained to. That was in an A320 - if you call that a "big aeroplane".