easyJet
Genoa and Seville now in the easyJet booking system both 2 x weekly from 2 June, both on Tue and Sat.
I make that 65 easyJet routes from BRS, albeit some are seasonal.
Ryanair operated Seville for three summers between 2009 and 2011 but I can't remember Genoa ever previously being operated as a regular route. Seville and Bristol are Airbus centres so there might be some passenger traffic as a result of that.
The easyJet timetable requires 15 based aircraft next summer (one more than in 2017), with part of August requiring 16 as things stand.