I heard of a cadet pilot at a reputable regional turboprop operator starting at 42 recently. Make sure you try as many airlines as possible, and above all make sure you have a good cover letter and polished CV to go with it. I work in an airline the amount of badly prepared applications that come across my desk is appalling.
Pay a bit of money to a career advisor and get a mock interview if you can. This will help you put the best possible step forward without having to travel too far.