There are several threads here on PPRuNe discussing the relative merits, or otherwise, of a pilotless commercial passenger jet, the subject has been done to death.
1. Until terrorism is totally under control, if not wiped out, remotely controlled pax aircraft won't happen. A ground based remotely controlled system will need to be 100% immune from any form of electronic 'hacking' and any form of suicidal terrorist attack.
2. Without 1., (above), the international insurance market won't touch it, no insurance = no fly.
3. The cost of overcoming 1 and 2 (above) - probably insurmountable and therefore not commercially viable within our lifetimes.
4. No one has presented verifiable figures on the cost benefit of a totally remotely controlled system versus what we have today. Simply getting rid of airborne pilots, in the great big scheme of things, may not be commercially viable at all. Fifteen hour sectors, one pilot? I don't think so.
5. Repeat 1. (above).