Possibly some thin transatlantic routes to Hartford, Pittsburgh, or Columbus/Cleveland etc but I imagine the bulk of the order will be short haul.
Being BA I can't see any of the frames going to the regions, with their continued focus to use LHR as a hub for connecting passengers from the east of the airport to the Americas.
I agree with the above post... BA have an opportunity to get ahead of the game. I imagine in the next 10 years the majority of flights to the North east coast of USa will be flown on narrow bodies, by an array of LCC's as seen with Norwegian and Primera from regional airports. If I was WW I would consider looking into using the neos from regional airports to NY/Boston etc, possibly where BA already have their foot in the door from domestic flights or even weekend cityflyer flights.