I don't think it's an issue to airlines, as long as you've got the licence they require. The issue might be learning all the different regulations.
I would definitely endorse getting an FAA PPL/IR for the cost/time benefit. ATPLs are always the biggest hurdle. Unless you have the right to work in the US, I wouldn't bother with the FAA CPL because it actually requires 50 hours more than the EASA CPL.