Waterford is back from 24th July (Mon/Tue/Thu)
The flights will be operated by a new airline, Aer Southeast, using a Saab 340 aircraft based at the airport. Prices will start from €79 each way.
Bookings can be made for London Luton via Waterford Airport's website (flywaterford.com) and aersoutheast.com from 9am on June 20.
Bookings for Manchester and Birmingham will be available shortly.
Six flights a week will operate to London Luton, the airport says, with three flights a week to each of Manchester and Birmingham.
Aer Southeast is an Irish aviation start-up with registered offices at Waterford Airport. It is run by SkyTruckers Ltd., a company with "very considerable experience in regional aviation and the backing of Irish and Scandinavian investors," according to a statement by the airport.