It depends on circumstances what style of flight I choose. If I'm on my own I'll go for cheapest flight on a reputable airline. Some I wont touch with a bargepole. So, find a flight at a moderately convenient time, eliminate the companies I won't use, then pick the cheapest of those that remain. Often enough it's a low cost. Surprise, surprise.
Travelling with my husband I'll be more fussy. He can't cope with sitting in an poor seating position for a long time and needs help walking. So we travel in far greater comfort, and may take an overnight stop to break a long journey. It's about informed choice. Something that technology has made possible.
In fairness, all the airlines seem to do well on helping disabled passengers. Although sometimes I end up trotting to keep up with the wheelchair pusher...😀