Originally Posted by
Afterglow
From my reading (but I maybe mistaken) the answers to those questions are not well known.
This is more or less correct. It's more accurate to say that the existing (few) large studies have shown either no link or an inconclusive link between fumes and the various proposed symptoms of 'aerotoxic'.
What's really required is a long term study of crew health with controls etc. Funding is an issue, and the science of detecting the effects and indeed the presence in the body is somewhat in it's infancy.
The science is well-understood, the problem is the limited number of samples and the time required for a proper study.
However some are making progress - this paper makes interesting reading:...
Interesting. However, the articles that cite it all seem to come to precisely the opposite conclusion.