Much cheaper to have a smart aircraft doing real-time targeting using dumb bombs - and smaller warheads where collateral damage is an issue - one
Add in all the costs associated with a strike package needed to hit 50 targets, well, I'd like to see your math. The exposure to crews over what would be a time protracted mission- you're not putting that many aircraft on target in the same 2-5 minutes the TLAMs took. This adds to the chances of seeing one of your aviators on Al Jazeera in Syrian hands or worse in ISIS hands ala the young Jordanian pilot.