BA flew MAN-LAX a few years ago with a B767, but pulled off the route, persumably due to poor loads.
I would guess that an A330-200 could manage MAN-LAX no problem, although if any pilots know differently please feel free to correct me.
Bmi said they wanted to start flying long haul to the far east, maybe Hong Kong or Singapore, but that they would need a different a/c to the A330.