Not completely relevant to OP's question, if I recall, FAA has a procedure called "statement of demonstrated ability" or similar.
Applied to an applicant I recall who didn't have full use of both legs and both arms/hands. Essentially, he went up with an examiner, proved he could do what he had to in operating the aircraft, and was approved. I don't know if that applies at the commercial or ATP levels.
So the answer, as always, is likely to be "check with your regulating authority regarding your specific case".