The problem for any remote airport and by that I mean away from main cities is the standing costs. Apart from the built structure there is a fuel farm and distribution system (even if that is just tankers), engineering equipment (both servicing and greater), cargo handling, stairs for access and specialised staff. This is on site for 365 days of the year. Asset wise, for handling large aircraft, we are talking millions for use 2 or 3 hours per week. The temptation would be to use cheaper very used gear but that throws up reliability and schedule issues. It gets worse when you throw in casual staff and the temptation to cutback on maintenance due to costs
While it is possible to contract some of the staffing, people like load masters and LAMEs wont work part time away from a city and FIFO isn't really an option either.
It is very hard to justify all this for 2 or 3 flights per week but without it there can be no reliable service. Clearly initially the loss will be tolerated but it may take years to even get to break even so in our instant return on investment era I cant see it
Wunwing
I'm trying to think of any cargo only airports that I have seen or heard for international freight. The only ones that come to mind are domestic US which are bases for outfits like FedEx and UPs etc and virtually all of those were hand me downs from the USAF so no real initial setup costs for buildings , fuel, runways and taxi ways.