I was on the 757 for three years and don't remember needing to understand this or why pilots need a very in-depth grasp of such system wiring, unless they decide not to look up a system fault in the correct (COM) cockpit operating manual etc. Normal procedures had the FO using the right, maybe the center autopilots. Knowing why not to change a normal procedure can be important, no doubt.
Do you have certain abnormal procedures done only from memory?
In later airplane systems, to reset or turn something off should only be per checklist, whether normal or abnormal, i.e never switch off the left recirc fan inflight, since the ovbd exhaust valve will be locked open and the cabin will climb over 1,000 feet per minute, with no way to close it! A captain tried this when the very hot cabin could not be cooled off, even in manual. Luckily, we were over land not far from the destination, considering that we descended immediately to "bring the cabin down" and the fuel burn increased a good bit.