I am sure many comments will be heavily biased to personal preference. I will pick up on just two for now.
I have flown in aircraft with a toilet behind the flight deck and one down the back. The time out of the office was minimised when using the forward position. OTOH the Mad Operator and Galley Slaves would possibly opt for one aft.
Windows? EO may be good but human eye has a far wider field of view. No matter how wide you create an EO display it will be in the operators central vision area. Looking out the window you can be alerted by peripheral vision.
Slewing an EO head may also take longer initially. Anyone remember the manual Vista Trackers on the Nimrod?