Winter use for the 330 fleet is going to be an issue as it expands. There may be limited use to LHR, or even MAD for IAG Cargo. I see them expanding use to the likes of FAO, AGP and maybe even down to the canaries.
South Africa would seem to be the most obvious long-haul service, traditional schedules to/from ZA are overnight both ways, which means a day 'wasted' in CPT or JNB. KLM do a daytime southbound flight to CPT, I don't know of any others. I imagine for utilisation purposes EI would operate daytime in one direction.
There are many connections over LHR to KUL and SIN, so those could also be options for direct service. SIN would connect to BA services to SYD. Realistically, these routes would need both the A350 and the new runway at DUB.