I've flown out of San Francisco several times on 747 non-stops back to London. The A380 departure didn't feel significantly different in terms of wind or routing from those 747s. The departure routing has been from one of the 28 runways (usually 28R I think) straight on over the peninsular ridge, turn right up the coast and right again through the Golden Gate. The only exception was a United 777 when we did a "Shoreline 9" departure (UA channel 9 was on) which was a very spirited departure and an immediate right turn after take off to follow (as far as I could tell) the shore of the Bay without crossing the Peninsular.
The weather when we arrived (on a 777 from London) was very different and we nearly diverted to Oakland apparently. We landed on 19R which I believe is pretty rare. The usual pattern I've seen at SFO has been 28 for landings and 1 for most departures with heavy departures using a 28.