Point taken. Not to be forgotten is the high level of work of all pilots these days. So it is not just a flight in isolation as for you, the pilots have to cope with repeated time zone changes and very disrupted sleep patterns, which make the relief crews and bunk rest so necessary. One of my colleagues has just completed this on a 3 week pattern:
LAX,OFF,SFO,OFFx2,SEA,OFF,JFK,OFF.
He's walking dead!