Generally, wide bodies, other than the costs/logistics operating equation, will send many to an early grave from circadian disruption. I am sure an EK participator may shed some light on these effect in modern aviation.
Narrow body, (in Aus) can been hectic although less back of clock, augmented operations through multiple time zones.
It all adds up. We need to remember, that as a vocation, we have a finite window to earn income. Medical standards or lack of them can knock your career on the head earlier these days. There is much risk in becoming a pilot. Little, if any, of it borne by the companies.
Look at insurance premiums for pilots. Actuaries know the real risks. Premium remuneration for this work should relate to the massive risk we take making it our primary income stream.