Skyscanner's Underserved Route of the Week is Bristol - Zurich
And I agree with their analysis of the best solution:
"In the humble opinion of our data elves, a double-daily Zurich connection with a SWISS code on the service would be the perfect addition to [bmi regional's] current network portfolio."
I suspect the challenge for BM, given recent information, would be finding an aircraft and crews to run another double-daily route from BRS.