The A380 produces 50% less cabin noise than a 747 and has higher cabin air pressure (equivalent to an altitude of 1500 metres (5000 ft) versus 2500 metres (8000 ft)); both features are expected to reduce the effects of travel fatigue.
Based on its maximum differential pressure of 8.6 psi, the A380 is capable of maintaining a 5000' cabin up to approximately 34,000' altitude.
The 747 (all series) has a max diff of 8.9 psi, which would allow a 5000' cabin up to around 35,800'.