Plus most people aren't very sensitive to cabin pressure differences.....
That is (mostly) true of flights of 6 hours or less. Above 6 hours it starts making a difference. Above 10 hours it starts making a big difference. Above 12 hours and it makes a difference to almost everyone, including the flight crew who are theoretically the most well adapted and least sensitive. The 787 (and A350?) also provide a more humid cabin environment. The lower cabin altitude and more humid environment combine to make a big difference on long haul flights.