Have to agree with all of the SLF comments who have to fly long haul on a regular basis.
SLF comfort is more a function of cabin configuration and service offering rather than the aircraft type, which can be addressed in part through cabin redesign. Emirates F-class 777 is arguably superior than F in A380. Same with F in BA 787 vs. BA A380.
Plus most people aren't very sensitive to cabin pressure differences and noise cancelling headphones equalize any cabin noise issues.
On the other hand if you're stuck in economy...