I donīt recall having any adverse effects taking Paludrine whilst serving in various places duing my time in the RAF. I did however get Malaria after a stint of working as a civilian on a small Indonesian island called Natuna.
I was taking Nivaquine prescribed by the then company doctor which obviously didnīt work as a prophylactic. After diagnosis I was treated and cured by a large dose of............yep, Nivaquine. Donīt recall any ill effects whilst taking it as a prophylactic either.