Assuming you're talking about turboprops, 2:1 profiles can have numerous advantages (can, not will). I used to fly them quite regularly.
For a straight-in approach, my rule of thumb was Height x 2, plus 4nm. This will bring you down a 2:1 slope to a point 10nm from the field at 3000', which on every turboprop I've flown was a comfortable place to be to decelerate, configure and be nice and stable as required, regardless of speed on the descent. Also means minimal adjustment to the profile is required if joining an instrument approach. So if you're at FL250 arriving at a sea level airfield, your top of descent will be 25 x 2 + 4 = 54nm.
If you're talking about jets - best of luck.