I'm left handed - have never had any problem driving cars with right hand or left hand drive.
My limited flying experience is nearly all right seat in C152/172 with a yoke, no problem flying right handed and had a trial lesson in a C152, left seat, left hand, no problem again.
Flying gliders with a stick however, my natural hand was the left - clonk round back of the head with a clip board from the instructor - "right hand m'boy, need your left hand for the cable release and spoilers - don't want to be changing hands during launch or landing do we...!"
I found flying right handed with a stick very hard but I suppose that had I persevered I would have trained it eventually.