MSB,
EK is stuck with the 380, and is in trouble if that line ever stops. Only 25% of the PAX carried stay in DXB. When they carry large 380 loads into DXB, they have large 380 loads to carry onwards. Having a hub half way between Europe and Asia makes this work for them. This is why they can use this aircraft to places like MRU, MAN and BHX.
Airlines without such a hub will never be able to consistently fill enough seats to be able to operate large fleets of 380s. In fact order books for anything with more than 300 seats are hurting.
So in reality there is only one airline where the high extra yield would be required to ensure no profit decline. For the rest replacing small fleets really wont make much difference.