I work with an MacBook for over a year now which has as only port an USB-C port. So far there are no problems with the port at all. Yes, it is slimmer, it can be inserted both ways and works still nicely, and apparently it is mechanically well constructed.
The only thing that will be confusing is the myriad of possible configurations with that single port, each can be set up differently. It can do 3.1 speeds, or only 3.0, can accept high amperage as a charging port or not, carry additional data streams like video data in display port protocol and so on. And then there is cables, which datarates do they support, which voltages? It will be kinda bad in my opinion.