Hybrid drives are great for specific tasks, however as always there are drawbacks.
The SSD part is effectively a large chunk of flash memory, your OS can be stored on this so the PC boots faster, a lot faster.
If it's large enough, your commonly used programs will also respond a lot quicker, if that is important to you fine.
The downside is SSD drives have a finite write cycle, a non-hybrid SSD will have much larger capacity and so will take longer to 'Wear out' as a different sector is used for every write to even out usage.
The other downside is the HDD media wears faster as most hybrid drives, power down the platter if they are working off the SSD portion, if they need access to the HDD, it then spins up so access to some files may actually seem longer. This spinning up and down is more wearing than keeping the platters spinning for long periods as in pure HDD's.
So, dedicated tasking which fits on the SSD, great because you'll get a consistently faster boot and response time. Multiple applications which won't all fit on the SSD with frequent accessing of storage would make hybrid drives non-viable imho.