Had two in two years on the CRJ 200. One at 220 in descent one at cruise @ 370.
No probs with diff; nor should there be. There are three panes & you can tell which one it is using qrh descriptions. No structural implications at all.
when it was my front one had to get the FO to land it coz I couldn't see out very well (could've managed if essential).
no deal really.