Hypothetically, of course. Really no need to dance on the head of a pin. We know exactly what the F-105D could do, and did. Both have (ended up with) the same basic mission, no? Both are single engine aircraft, though the F-35A has a significantly more powerful engine. For the F-35A, let's go with LM's sales brochure numbers.
On Day 2, with external ordnance and drops, the F-105D goes way farther, waay faster, and drops waaay more bombs than a clean F-35A, no? Add externals to the F-35A, and now the F-105D goes waay farther, waaay faster, and drops way more bombs than a F-35A. Isn't that right?
Let's just talk Day 2 for awhile.