Without the bachelor degree, it will be very hard to get hired at a major. Not impossible, but it's good that you are working on it now. Getting some recency in 121 won't hurt at all, but obviously it'll be tough on the finances until you can get hired somewhere. Pay had improved recently and everyone is hiring.
You may have a chance right away with Frontier Airlines. You may have a shot with some ACMI carriers as well.
There are lots of choices so let us know if you have any questions.